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KMID : 1120320170030030132
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Osteoporosis and Sarcopenia
2017 Volume.3 No. 3 p.132 ~ p.137
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Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis
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Fouda Abdel-Motaal
Youssef Amany Ragab
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Abstract
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Objectives: The effect of Salvadora persica sticks on prevention of tooth decay is well established, but the effect of S. persica stick extract (SPE) on the prevention/treatment of osteoporosis has not been studied. The purpose of this study is to provide baseline information of the effectiveness of SPE on ovariectomized (OVX) rat model of osteoporosis.
Methods: SPE was administered at 50, 150, and 300 mg/d orally to OVX rats for 16 weeks. Serum osteocalcin, alkaline phosphatase, calcium, and phosphorus, and urinary deoxypyridinoline, calcium, and phosphorus were measured. Bone mineral density (BMD), 3-point bending test, and histomorphometric characteristics of the femoral bone were also examined.
Results: SPE at doses of 150 and 300 mg/d, but not 50 mg/d, significantly prevented bone loss in OVX rats as proved by decreased biochemical markers of bone resorption and increased BMD and biomechanical indices of the femoral bone.
Conclusions: This study confirms a dose-dependent protective action of SPE on rat OVX model of osteoporosis. This effect needs further investigation at the molecular and clinical levels to provide a natural and cost-effective alternative for the management of postmenopausal osteoporosis.
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KEYWORD
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Osteoporosis, Salvadora persica, Ovariectomy, Osteocalcin
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